Publications

2024

M.R. Wensveen, A.A. Dixit, R. van Schendel, A. Kendek, J.P. Lambooij, M. Tijsterman, SU Colmenares, A Janssen. Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair. Nature Communications (2024)

Yuheng Huang, Yi Gao, Kayla Ly, Leila Lin, Jan Paul Lambooij, Elizabeth G. King, Aniek Janssen, Kevin H.-C. Wei, Yuh Chwen G. Lee. Varying recombination landscapes between individuals are driven by polymorphic transposable elements. bioRxiv (Sept, 2024)

A. Kendek*, A. Sandron*, J.P. Lambooij, S.U. Colmenares, S.M. Pociunaite, I. Gooijers, L. de Groot, G.H. Karpen and A. Janssen. DNA Double-Strand Break Movement in Heterochromatin Depends on the Histone Acetyltransferase dGcn5. Nucleic Acids Research (2024)

M. A. E. van Bueren and A. Janssen. The impact of chromatin on double-strand break repair: imaging tools and discoveries. DNA repair (2024).

2021

A. Kendek*, M.R. Wensveen*, A. Janssen. The sound of silence: How silenced chromatin orchestrates the repair of double-strand breaks. Genes (2021).

2020

W.H.M. Hoevenaar, A. Janssen*, A.I. Quirindongo*, H. Ma*, S.J. Klaasen, A. Teixeira, B. van Gerwen, N. Lansu, F.H.M. Morsink, G.J.A. Offerhaus, R.H. Medema, G.J.P.L. Kops**, N. Jelluma**. Degree and site of chromosomal instability define its oncogenic potential. Nature Communications (2020)

2019

A. Janssen*, S.U. Colmenares*, T. Lee and G.H. Karpen. Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A Genes and Development (2019).

2018

A. Janssen*, S. U. Colmenares*, G. H. Karpen. Heterochromatin: Guardian of the Genome Ann. Rev. Cell. Dev. Biol (2018)

2016

A. Janssen, G. Breuer, E. Brinkman, A. van der Meulen, S. Borden, B. van Steensel, R. Bindra, J. LaRocque and G. Karpen. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin Genes and Development (2016).

A Koch, A Maia, A. Janssen, R.H. Medema. Molecular basis underlying resistance to Mps1/TTK inhibitors. Oncogene. (2016)

2015

A.R. Maia, J. de Man, U. Boon, A. Janssen, J.Y. Song, M. Omerzu, J.G. Sterrenburg, M.B. Prinsen, N. Willemsen-Seegers, J.A. de Roos, A.M. van Doornmalen, J.C. Uitdehaag, G.J. Kops, J. Jonkers, R.C. Buijsman, G.J. Zaman, R.H. Medema. Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model. Ann Oncol. (2015)

2013

A. Janssen*, E. Beerling, R*. Medema** and J. van Rheenen**. Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy. PLoS One (2013)

A. Janssen, R. H. Medema. Cancer: Stress mixes chromosomes Nature. (2013)

A. Janssen, R. H. Medema. Genetic instability: tipping the balance Oncogene. (2013)

2011

A. Janssen, M. van der Burg, K.Szuhai, G.J.P.L. Kops, R.H. Medema, Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations Science (2011)

A. Janssen, R. H. Medema. Mitosis as an anti-cancer target Oncogene (2011).

A.Janssen, R. H. Medema. Entosis: aneuploidy by invasion Nat Cell Biol (2011).

2009

A. Janssen, G. J. Kops, R. H. Medema, Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells Proc Natl Acad Sci U S A (2009).

M. E. Tanenbaum, L. Macůrek, A. Janssen, E.F. Geers, M. Alvarez-Fernández, R.H. Medema, Kif15 cooperates with eg5 to promote bipolar spindle assembly Curr Biol (2009).